10.30–11.15 Dr. Jaakko NIEMINEN: Uncovering dreams within sleep with magnetic brain stimulation and EEG
11.15 – 11.30 Questions and discussion
11.30–12.15 Dr. Jaakko NIEMINEN: Multi-locus transcranial magnetic stimulation
Auditorium 2, Sverdrups Hus (Universitetsbiblioteket), Blindern,
Moltke Moes vei 39 ved/Blindernveien, 0317 Oslo
All are welcome!
ABSTRACT for the first lecture (taken from an article by Nieminen et al. 2016*):
When subjects become unconscious, there is a characteristic change in the way the cerebral cortex responds to perturbations, as can be assessed using transcranial magnetic stimulation and electroencephalography (TMS-EEG). For instance, compared to wakefulness, during non-rapid eye movement (NREM) sleep TMS elicits a larger positive-negative wave, fewer phase-locked oscillations, and an overall simpler response. However, many physiological variables also change when subjects go from wake to sleep, anesthesia, or coma. To avoid these confounding factors, we focused on NREM sleep only and measured TMS-evoked EEG responses before awakening the subjects and asking them if they had been conscious (dreaming) or not. As shown here, when subjects reported no conscious experience upon awakening, TMS evoked a larger negative deflection and a shorter phase-locked response compared to when they reported a dream. Moreover, the amplitude of the negative deflection-a hallmark of neuronal bistability according to intracranial studies-was inversely correlated with the length of the dream report (i.e., total word count). These findings suggest that variations in the level of consciousness within the same physiological state are associated with changes in the underlying bistability in cortical circuits.
ABSTRACT for the second lecture:
«I will present the multi-locus transcranial magnetic stimulation of the brain (mTMS) instrumentation that we have develop at Aalto University and some mTMS–electromyography results. Our mTMS device allows hanging the stimulation target electronically without any coil movement.»
Sponsored by the Human Brain Project and SERTA: The Changing Brain